Effect of sarcopenia on the prognosis of patients with hepatocellular carcinoma after laparoscopic radical surgery
10.3760/cma.j.cn113884-20240505-00133
- VernacularTitle:肌肉减少症对肝细胞癌患者腹腔镜根治术后预后的影响
- Author:
Xingbo WEI
1
;
Yifan ZHI
;
Changqian TANG
;
Jizhen LI
;
Hengli ZHU
;
Yuqi GUO
;
Yongnian REN
;
Zuochao QI
;
Dongxiao LI
;
Deyu LI
Author Information
1. 河南大学人民医院肝胆胰腺外科，郑州 450003
- Keywords:
Carcinoma, hepatocellular;
Sarcopenia;
Hepatectomy;
Prognosis
- From:
Chinese Journal of Hepatobiliary Surgery
2024;30(9):641-645
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the effect of sarcopenia on the prognosis of patients with hepatocellular carcinoma (HCC) after laparoscopic radical resection.Methods:Clinical data of 165 patients with HCC undergoing laparoscopic radical resection in Henan University People's Hospital from January 2018 to December 2021 were retrospectively analyzed, including 122 males and 43 females, aged (55.5±11.4) years. Patients were divided into sarcopenia group ( n=79) and control group (non-sarcopenia, n=86) according to the skeletal muscle index. The survivals were analyzed using the Kaplan-Meier method, and were compared by the log-rank test. Univariate and multivariate Cox regression were utilized to analyze the effect of sarcopenia on the prognosis of HCC after laparoscopic radical surgery. Results:The 1- and 3-year cumulative survival rates of control group were 96.4% and 81.2%, which were higher than those of the sarcopenia group (83.2% and 48.9%, respectively, χ2=19.67, P<0.001). The 1- and 3-year recurrence-free survival (RFS) rates of control group were 88.4% and 66.1%, which were higher than those of sarcopenia group (70.9% and 37.7%, respectively, χ2=18.80, P<0.001). Multivariate Cox regression analysis showed that the risk of recurrence ( HR=1.35, 95% CI: 1.20-1.59, P<0.001) and the risk of death ( HR=2.21, 95% CI: 1.23-3.41, P=0.001) after laparoscopic radical resection for HCC in patients with sarcopenia rises compared to non-sarcopenic patients. Conclusion:Sarcopenia is a risk factor for the survival and recurrence of HCC after laparoscopic radical surgery.
