Research progress of effect on M2-type polarization of Kupffer cells in hepatic ischemia-reperfusion injury
10.3760/cma.j.cn113884-20240512-00137
- VernacularTitle:肝缺血再灌注损伤中肝驻留巨噬细胞M2型极化作用的研究进展
- Author:
Jiajing QIU
1
;
Qiang ZHU
Author Information
1. 南京医科大学附属儿童医院（南京儿童医院）普外科，南京 210000
- Keywords:
Reperfusion injury;
Liver;
Kupffer cells;
M2 macrophages;
Polarization
- From:
Chinese Journal of Hepatobiliary Surgery
2024;30(8):625-630
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic ischemia-reperfusion injury (HIRI), as an unavoidable complication after liver surgery such as liver transplantation, can lead to postoperative hepatic impairment or even hepatic failure, which threatens patients' lives. As an important component of immune cells, macrophages have a key role in the process of HIRI. The polarization of liver resident Kupffer cells (KCs) plays a completely opposite role in HIRI. The polarization of KCs toward M2 cells antagonizes the pro-inflammatory response caused by M1 polarization and thus protects against liver injury. However, the signaling pathways of KCs polarized toward M1 or M2 are not yet fully understood. The in-depth elucidation of the role of M2 type polarization can further guide the development of subsequent targeted drugs, which will play an important role in alleviating or curing HIRI. The authors summarize the relevant applications and possible signaling pathways involved in the role of M2-type polarization of hepatic macrophages in HIRI, which will provide references for the development of clinically targeted drugs in the future.
