Analysis of the impact of graft to recipient body weight ratio on the efficacy of living donor liver transplantation in infants with biliary atresia
10.3760/cma.j.cn113884-20240311-00066
- VernacularTitle:移植物体重比对胆道闭锁婴儿活体肝移植术后疗效的影响
- Author:
Tingge WANG
1
;
Mingman ZHANG
;
Yuhua DENG
;
Yan HU
;
Xiaoke DAI
;
Yingcun LI
Author Information
1. 重庆医科大学附属儿童医院儿童保健科 国家儿童健康与疾病临床研究中心 儿童发育疾病研究教育部重点实验室 儿童神经发育与认知障碍重庆市重点实验室，重庆 400014
- Keywords:
Biliary atresia;
Living donor liver transplantation;
Graft to recipient body weight ratio;
Curative effect
- From:
Chinese Journal of Hepatobiliary Surgery
2024;30(8):576-580
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effects of different graft to recipient body weight ratio (GRWR) on the efficacy of living donor liver transplantation (LDLT) in infants with biliary atresia (BA).Methods:Clinical data of 175 BA infants, including 98 males and 77 females, age at transplantation was 5.40 (4.77, 6.33) months, who underwent LDLT at the Department of Hepatobiliary Surgery, Children’s Hospital of Chongqing Medical University from May 2018 to December 2022 were retrospectively analyzed. They were divided into the routine GRWR group (2%≤GRWR≤ 4%, n=121) and high GRWR group (GRWR>4%, n=54). The preoperative general condition, intraoperative condition and postoperative recovery of children in the two groups were compared. Survival analysis was performed by using Kaplan-Meier method, and log-rank test was used to compare survival differences. Results:A total of 16 (9.14%, 16/175) children underwent unplanned surgery after LDLT. There were statistically significant differences in weight at LDLT and graft weight between children in the routine GRWR and high GRWR groups (both P<0.05). There were no statistically significant difference between the two groups in terms of operative time, intraoperative bleeding, and postoperative complication rates (all P>0.05). There were no hepatic artery thrombosis or stenosis occurred in the children of both groups after LDLT. The cumulative survival rates of the children in the routine GRWR group were 97.5% and 95.5% at 1 and 3 years after LDLT, respectively, and 96.3% and 94.2% at 1 and 3 years after LDLT in the high GRWR group, and the difference in cumulative survival rates between the two groups was not statistically significant ( P=0.692). Conclusion:The use of liver grafts with GRWR >4% is also safe and effective for LDLT in infants with BA, which supposes that may not be necessary to reduce the transplanted liver volume in children LDLT with high GRWR.
