Analysis of the risk factors for metastasis of hepatic alveolar echinococcosis
10.3760/cma.j.cn113884-20231216-00168
- VernacularTitle:肝泡型包虫病远处转移的危险因素分析
- Author:
Aimaiti DILIMURETI
1
;
Peng YU
;
Ahan AYIFUHAN
;
Shaobin DUAN
Author Information
1. 新疆医科大学附属中医医院普通外科，乌鲁木齐 830054
- Keywords:
Echinococcosis, hepatic;
Risk factors;
Metastasis
- From:
Chinese Journal of Hepatobiliary Surgery
2024;30(8):572-575
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the risk factors that affects the metastasis of hepatic alveolar echinococcosis (HAE).Methods:Clinical data of 138 patients with HAE admitted to the Xinjiang Medical University Affiliated Traditional Chinese Medicine Hospital and the First Affiliated Hospital of Xinjiang Medical University between January 2016 and January 2022 were retrospectively analyzed, including 79 males and 59 females, aged (39.6±11.7) years old. Patients were divided into two groups according to the presence of metastatic lesions of HAE: the metastasis group ( n=58) and non-metastasis group ( n=80). Clinicopathological data including the lesion location, lesion size, serum albumin level, eosinophil count, and echinococcus granulosus cystic fluid (EgCF) were collected. Multivariate logistic regression analysis was utilized to identify the risk factors of metastasis. Results:Statistically significant differences were observed between the metastasis group and non-metastasis group in terms of gender, ethnicity, involvement of adjacent organs, EgCF status, serum albumin level, maximum lesion diameter, disease duration, and eosinophil count (all P<0.05). The results of multivariate logistic regression analysis showed that patients from the minority ethnic groups ( OR=5.674, 95% CI: 1.769-18.204, P=0.004), with involvement of adjacent organs ( OR=3.821, 95% CI: 1.367-10.680, P=0.011), positive EgCF ( OR=3.460, 95% CI: 1.093-10.951, P=0.035), larger maximum lesion diameters ( OR=1.116, 95% CI: 1.012-1.230, P=0.027), longer disease durations ( OR=1.009, 95% CI: 1.001-1.018, P=0.036), and lower eosinophil count ( OR=0.799, 95% CI: 0.701-0.911, P=0.001) were at higher risk of developing distant metastases. Conclusion:Ethnic minorities, involvement of adjacent organs, positive EgCF, large lesion length, long disease duration, and low eosinophil count are independent risk factors for distant metastasis in patients with HAE.
