Research progress of ferroptosis and ischemia-reperfusion injury
10.3760/cma.j.cn113884-20240430-00128
- VernacularTitle:铁死亡与缺血再灌注损伤的研究进展
- Author:
Longcan YANG
1
;
Yongxia CHEN
;
Hao LUO
;
Yuyou HUANG
;
Xiaobin REN
;
Bo LIU
;
Zhaoming HU
;
Xufei TIAN
;
Feng ZHANG
Author Information
1. 铜仁市人民医院肝胆外科，铜仁 554300
- Keywords:
Ferroptosis;
Ischemia-reperfusion injury;
Cancer
- From:
Chinese Journal of Hepatobiliary Surgery
2024;30(7):556-560
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a kind of programmed cell death, involves multi-molecular and multi-signaling pathways, and the core processes is iron overload and lipid peroxidation. It affects cancer, neurological disease, cardiovascular disease, digestive system disease, and many other diseases. While, ischemia-reperfusion injury is an extremely complex pathological process, including ischemia-reperfusion injury of the heart, brain, liver and kidney, etc., which often occurs in shock, organ surgery and organ transplantation, seriously affecting human health, and there is no effective radical treatment. However, ferroptosis is closely related to ischemia-reperfusion injury so that it is possible to find the prevention and treatment measures of ischemia-reperfusion injury by exploring the internal relationship between them. Therefore, the author tries to summarize the signaling pathways of ferroptosis, and explores the relationship between ferroptosis and ischemia-reperfusion injury of heart, brain, liver and kidney by moderating the ferroptosis targets properly to find the effective ways to treat cancer, improve inflammation and relieve other diseases.
