Advances in organoids of liver cancer
10.3760/cma.j.cn113884-20240429-00125
- VernacularTitle:原发性肝癌类器官研究进展
- Author:
Yueyi SUN
1
;
Binwei DUAN
Author Information
1. 首都医科大学附属北京佑安医院普通外科中心 北京肝病研究所 首都医科大学肝癌临床诊疗及研究中心，北京 100069
- Keywords:
Liver neoplasms;
Organoids;
Drug screening assays
- From:
Chinese Journal of Hepatobiliary Surgery
2024;30(7):549-552
- CountryChina
- Language:Chinese
-
Abstract:
Organoid technology for primary liver cancer presents a novel in vitro model that faithfully reproduces the tissue architecture and genetic characteristics of liver cancer, serving as a platform for drug efficacy testing and disease mechanism exploration. Despite hurdles such as modest cultivation success rates and the challenge of fully mimicking the tumor microenvironment, the progression of liver cancer organoid technology holds the potential for advancing personalized medicine and tailored therapies, positioning it as a critical instrument in the investigation of liver cancer treatment strategies. This review delineates the techniques for construction methods of liver cancer organoids, their applications, and the existing constraints.
