Research progress of ubiquitin-specific proteases in pancreatic cancer

VernacularTitle:泛素特异性蛋白酶家族在胰腺癌中的研究进展
Author: Xing LIANG ¹ ; Chenghao SHAO ; Xiaoqiang DONG ; Keqi WANG
Author Information

1. 海军军医大学第二附属医院胰胆外科，上海　200003
Keywords: Pancreatic neoplasms; Deubiquitination; Ubiquitin-specific peptidases; Inhibitor of ubiquitin-specific peptidase
From: Chinese Journal of Hepatobiliary Surgery 2024;30(6):472-476
CountryChina
Language:Chinese
Abstract: Ubiquitination and deubiquitination are common post-translational modifications of proteins. As the largest family of deubiquitinating enzymes, ubiquitin-specific proteases (USPs) play critical roles in various physiological and pathological processes. Dysregulation of their functions results in a series of physiological damages and pathological alterations, ultimately contributing to the occurrence and progression of malignant tumors, including pancreatic cancer. Currently, research on the functional mechanisms of deubiquitinating enzymes in pancreatic cancer is still limited. This review focused on the research progress of USPs family in the occurrence and development of pancreatic cancer, to elucidate their impacts on the malignant biological behaviors of pancreatic cancer and its underlying mechanisms. The therapeutic potential of USPs inhibitors in pancreatic cancer were also discussed.