Research advances in the role and mechanisms of immune cells in the acidic microenvironment of hepatocellular carcinoma
10.3760/cma.j.cn113884-20240102-00003
- VernacularTitle:肝细胞癌酸性微环境下免疫细胞的作用和机制的研究进展
- Author:
Yingjian HOU
1
;
Boshi WANG
;
Youyi LIU
;
Cheng JIN
Author Information
1. 江南大学附属医院肝胆外科，无锡 214122
- Keywords:
Carcinoma, hepatocellular;
Tumor microenvironment;
Tumor escape;
Immunotherapy;
Immune cells
- From:
Chinese Journal of Hepatobiliary Surgery
2024;30(5):386-390
- CountryChina
- Language:Chinese
-
Abstract:
The gradually acidified tumor microenvironment plays a key role in the formation and advance of hepatocellular carcinoma. Under the regulation of acidic microenvironment, the differentiation and function of immune cells change to immunosuppression, which further leads to the occurrence of immune escape of hepatocellular carcinoma. In this paper, the formation of acidic microenvironment of hepatocellular carcinoma, the changes of various immune cells in acidic microenvironment and their effects on the occurrence and development of hepatocellular carcinoma, as well as their further mechanisms are reviewed in order to provide new ideas for the study of immunotherapy of hepatocellular carcinoma.
