Research progress in factors influencing the polarization of macrophages by hyperthermia

VernacularTitle:热疗对巨噬细胞极化影响因素的研究进展
Author: Wei WANG ¹ ; Yun SHAO ; Yuan CONG ; Yuying YANG ; Shengzhi WANG
Author Information

1. 青岛大学口腔医学院，青岛　266003
Keywords: Tumor-associated macrophages; Tumor microenvironment; Hyperthermia; Oxidative stress
From: Chinese Journal of Radiation Oncology 2024;33(12):1164-1169
CountryChina
Language:Chinese
Abstract: Hyperthermia, as an adjunct to radiotherapy and chemotherapy, can change the immune condition of tumor microenvironment and enhance the effect of tumor treatment without damaging normal tissues. Tumor-associated macrophages are the main immune cells in the tumor microenvironment, and there are two subtypes: M1 phenotype can inhibit the growth of tumor cells, and M2 phenotype can promote the occurrence and metastasis of tumor cells. Therefore, repolarization of M2 phenotype into M1 phenotype is a new research direction. In this paper, the mechanisms of hyperthermia and tumor-associated macrophage repolarization were reviewed based on the current research progress at home and abroad, aiming to provide novel ideas for tumor therapy.