Research progress in low-dose radiation therapy for Alzheimer's disease

VernacularTitle:低剂量放射治疗阿尔茨海默病的研究进展
Author: Xi QI ¹ ; Weiping WANG ; Kai LIU ; Xianhe ZHAO ; Ke HU ; Fuquan ZHANG
Author Information

1. 中国医学科学院北京协和医学院，北京协和医院放射治疗科，北京　100730
Keywords: Alzheimer disease; Low-dose radiotherapy; Amyloid β-protein; Inflammation
From: Chinese Journal of Radiation Oncology 2024;33(11):1077-1081
CountryChina
Language:Chinese
Abstract: Alzheimer's disease is a serious neurodegenerative disease without effective treatment. In recent years, researchers have tried to treat Alzheimer's disease with low-dose radiation therapy (LDRT) and have made some progress in animal models and clinical trials. Current studies have shown that LDRT can improve cognitive function in Alzheimer's patients by reducing β amyloid plaque deposition and reducing inflammation levels in central nervous system. In this review, we present the current preclinical and clinical studies, propose the possible mechanisms of LDRT in Alzheimer's disease, and discuss challenges in the planning of future trials.