Research progress in radiation-induced skin injury
10.3760/cma.j.cn113030-20240417-00143
- VernacularTitle:放射性皮肤损伤的研究进展
- Author:
Jinlong WEI
1
;
Qin ZHAO
;
Jincai LYU
;
Zining TAN
;
Xuanzhong WANG
;
Qifeng WANG
;
Jinbo YUE
;
Pei YANG
;
Wencheng ZHANG
;
Shuang LI
;
Ye ZHANG
;
Xin JIANG
;
Bing WANG
Author Information
1. 吉林大学第一医院放疗科，吉林省肿瘤精准放射治疗重点实验室，吉林大学公共卫生学院国家卫健委放射生物学重点实验室，长春 130021
- Keywords:
Neoplasms;
Radiotherapy;
Radiation-induced skin injury;
Mechanism of injury
- From:
Chinese Journal of Radiation Oncology
2024;33(11):1024-1032
- CountryChina
- Language:Chinese
-
Abstract:
Radiotherapy is one of the main treatment methods for malignant tumors, which can cause the radiation damage to normal tissues. Radiation-induced skin injury (RISI) is one of the main adverse reactions caused by radiotherapy. The main clinical manifestations of RISI are dermatitis, ulcer, erosion and necrosis, which seriously affect the quality of life and treatment effect of tumor radiotherapy patients, and even affect the overall survival of patients. The pathological mechanism of RISI is still unclear. Some studies have shown that inflammation and oxidative stress are the main causes of RISI. RISI can be divided into acute and chronic RISI according to the different onset time, and different treatment strategies can be formulated according to the severity of the injury. In this article, clinical manifestations, classification, pathogenesis, prevention and treatment of RISI are comprehensively summarized.
