Research progress in radiation-induced heart disease
10.3760/cma.j.cn113030-20231212-00196
- VernacularTitle:放射性心脏损伤的研究进展
- Author:
Xin WANG
1
;
Ye ZHANG
;
Qifeng WANG
;
Jinbo YUE
;
Pei YANG
;
Wencheng ZHANG
Author Information
1. 天津医科大学肿瘤医院放疗科，国家恶性肿瘤临床医学研究中心，天津市恶性肿瘤临床医学研究中心，天津市肿瘤防治重点实验室，天津 300060
- Keywords:
Neoplasms;
Radiotherapy;
Radiation-induced heart disease;
Mechanism of injury
- From:
Chinese Journal of Radiation Oncology
2024;33(11):1007-1015
- CountryChina
- Language:Chinese
-
Abstract:
Cardiotoxicity is traditionally regarded as the late toxic side effect of radiotherapy. Classical radiobiology suggests that non-proliferative and highly-differentiated tissues, such as the heart, should exhibit robust resistance to ionizing radiation. However, in-depth analyses of radiation-induced heart disease (RIHD) have discovered that radiation can induce a range of physiological changes in the heart. These changes, which include endothelial dysfunction, inflammation, thrombosis, and cardiac fibrosis, may be significantly accelerated as radiation doses increase. At present, multidisciplinary team treatment modalities have substantially enhanced curative effects for cancer patients. However, the resulting prolongation of survival time exposes a larger patient population to the risks of treatment-related cardiotoxicity, establishing RIHD as a pressing research concern. This article offers a systematic review of recent insights into the incidence of RIHD, the relationship between radiotherapy and RIHD, methods for its detection and diagnosis, as well as its pathogenesis and potential treatment strategies.
