Research progress in radiation induced hearing loss
10.3760/cma.j.cn113030-20240214-00059
- VernacularTitle:放射性听力损伤的研究进展
- Author:
Ruichen LI
1
;
Ye ZHANG
;
Qifeng WANG
;
Jinbo YUE
;
Pei YANG
;
Wencheng ZHANG
;
Xiaoshen WANG
Author Information
1. 复旦大学附属眼耳鼻喉科医院放疗科，上海 200031
- Keywords:
Head and neck neoplasms;
Radiotherapy-induced hearing loss;
Mechanism of injury;
Radiation dose;
Eustachian tube;
Cochlea
- From:
Chinese Journal of Radiation Oncology
2024;33(11):993-998
- CountryChina
- Language:Chinese
-
Abstract:
Hearing loss is one of the common radiotherapy-induced complications of head and neck tumors, including nasopharyngeal carcinoma. These side reactions can be classified into acute or delayed types, which affect all structures of the auditory organs, resulting in conductive, sensorineural or mixed hearing loss. Up to 40% of patients develop acute middle ear side effects during radical radiotherapy, while approximately 1/3 develop late sensorineural hearing loss. The total radiation dose and tumor site appear to be the most important factors associated with the risk of hearing loss. The mechanisms of conductive and sensorineural hearing impairment are different. New radiotherapy techniques (three-dimensional conformal radiotherapy, intensity modulated radiotherapy, proton therapy) enable better dose distribution, lower dose to non-target organs, and gradually increase the feasibility of protecting normal tissues. The present article illustrates recent progress in radiotherapy-induced hearing loss, specially focusing on the occurrence, the mechanisms and related factors of ear toxicity, detection and diagnosis, and treatment.
