Research progress on abscopal effect of radiotherapy combined with immunotherapy for malignant tumors
10.3760/cma.j.cn113030-20240305-00089
- VernacularTitle:联合免疫治疗后恶性肿瘤放疗远隔效应的研究进展
- Author:
Shengying ZHOU
1
;
Xingchen DING
;
Yong WANG
;
Man HU
Author Information
1. 山东第二医科大学临床医学院，潍坊 261053
- Keywords:
Radiotherapy;
Abscopal effects;
Radiotherapy combined with immunotherapy;
Tumor microenvironment
- From:
Chinese Journal of Radiation Oncology
2024;33(10):964-970
- CountryChina
- Language:Chinese
-
Abstract:
Abscopal effect (AE) is defined as the phenomenon that the non-irradiated lesions shrink in addition to the directly irradiated lesions when the tumors are treated with radiotherapy. With widespread application of programmed cell death receptor-1 (PD-1), programmed cell death ligand-1 (PD-L1), cytotoxic T-lymphocyte-associated protein 4 (CTL-4) antibody, the treatment of malignant tumors has entered the era of immunotherapy. With the increasing application of radiotherapy combined with immunotherapy, AE has received unprecedented attention from scholars. The combination of radiotherapy and immunotherapy can promote the occurrence of systemic immune response and enhance the anti-tumor response of radiotherapy, which has deepened the understanding of AE. In this article, the history of AE in different stages of radiotherapy was reviewed, and the factors, possible mechanisms and clinical research status affecting the incidence of AE were emphasized, aiming to increase the incidence of AE in the era of immunotherapy, promote the objective effectiveness of radiotherapy combined with immunotherapy in clinical application, and further improve clinical prognosis of patients with malignant tumors.
