Application of non-coding RNAs in radiotherapy resistance in head and neck tumors
10.3760/cma.j.cn113030-20240207-00050
- VernacularTitle:非编码RNA在头颈肿瘤放射抵抗中作用的研究进展
- Author:
Yuyi LI
1
;
Chao TAN
;
Feng LIU
;
Kailin CHEN
;
Hui WANG
Author Information
1. 南华大学衡阳医学院 湖南省肿瘤医院研究生协作培养基地，衡阳 421001
- Keywords:
Radiotherapy;
Non-coding RNA;
Radioresistance;
Neoplasms;
Radiotherapy sensitization
- From:
Chinese Journal of Radiation Oncology
2024;33(10):958-963
- CountryChina
- Language:Chinese
-
Abstract:
Radiotherapy plays a key role in the treatment of head and neck tumors, which can not only serve as a curative treatment, but also as an adjuvant treatment after surgery to improve the local control rate. In addition, radiotherapy also helps preserve important organ functions, such as laryngeal function or facial appearance, which is of great significance for the treatment and rehabilitation of patients. Despite advances in radiotherapy technology, some patients still experience resistance to radiation therapy, resulting in treatment failure. Non-coding RNA (ncRNA) is considered to be the main type of RNA transcription, which is usually not translated into proteins, and mainly functions through the interaction with proteins, chromatins and mRNAs, and is a molecular marker for a variety of tumors, involving tumor proliferation, apoptosis, invasion and migration, etc. Many studies have shown that dysregulated ncRNA play an important role in radiotherapy resistance in head and neck tumors. Therefore, this article reviews the research progress of ncRNA in radiotherapy resistance in head and neck tumors, aiming to better understand the role of ncRNA in the occurrence and development of radiotherapy resistance, and provide reference for formulating more effective strategies for preventing radiotherapy resistance.
