Ferroptosis: new opportunities for radiosensitization
10.3760/cma.j.cn113030-20240303-00086
- VernacularTitle:铁死亡：肿瘤放疗增敏新机遇
- Author:
Ziqiang SHEN
1
;
Yichu SUN
;
Fei LIANG
;
Jing YANG
;
Chong ZHOU
;
Youyou XIA
Author Information
1. 南京医科大学连云港临床医学院（连云港市第一人民医院）放疗科，连云港 222000
- Keywords:
Radiotherapy;
Ferroptosis;
Nanomedicine;
Neoplasms
- From:
Chinese Journal of Radiation Oncology
2024;33(9):864-869
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a novel form of cell death discovered in recent years, characterized by iron-dependent cell death featuring the peroxidation of polyunsaturated fatty acid phospholipids. Recent studies have found that radiotherapy can induce ferroptosis in tumor cells through ionizing radiation, and the combination of radiotherapy with small molecule or nano-scale ferroptosis inducers can inhibit tumor growth and enhance radiosensitization. This review summarizes the mechanisms of ferroptosis and the pathways through which radiotherapy induces ferroptosis, and also explores the potential application prospects of small molecule drugs and nanomaterials in mediating ferroptosis for the radiosensitization of tumor treatment.
