Research status and prospects of proton therapy for breast cancer
10.3760/cma.j.cn113030-20231123-00174
- VernacularTitle:乳腺恶性肿瘤质子放疗的研究现状与前景
- Author:
Xiaoyu WU
1
;
Mei CHEN
;
Lu CAO
;
Min LI
;
Yibin ZHANG
;
Gang CAI
;
Jiayi CHEN
Author Information
1. 上海交通大学医学院附属瑞金医院放疗科，上海 200025
- Keywords:
Breast neoplasms;
Radiotherapy;
Proton therapy
- From:
Chinese Journal of Radiation Oncology
2024;33(8):772-777
- CountryChina
- Language:Chinese
-
Abstract:
Radiation therapy is an essential component of comprehensive treatment for breast cancer. In comparison to photons, proton beam, with its unique Bragg peak, limits the dose distribution to normal tissues around the tumor while improving dose coverage within the target area. Therefore, it could be an appealing therapeutic option for breast cancer treatment. Current researches indicate that proton therapy for breast cancer treatment has a distinct dosimetric advantage in protecting the heart and lungs. However, there are potentially increased risks of side-effects such as skin reactions and rib fractures, etc. Future Subsequent studies should seek a better understanding of the relative biological effectiveness changes along the proton beam range to improve the proton plan evaluation. Additionally, efforts should be directed towards identifying patients who would derive maximum benefit from proton therapy, addressing concerns related to its limited accessibility and high cost. This review provides an overview of the current clinical experiences, research progress and controversies in proton therapy for breast cancer.
