Application of "multimodal cocktail therapy" in the treatment of advanced malignant tumors
10.3760/cma.j.cn113030-20231013-00130
- VernacularTitle:多模态合一鸡尾酒疗法在晚期恶性肿瘤治疗中的应用
- Author:
Jianglin CHEN
1
;
Zhibing WU
Author Information
1. 浙江中医药大学第二临床医学院，杭州 310053
- Keywords:
Neoplasms, malignant advanced;
Thermal therapy;
Multimodal therapy;
Cocktail therapy;
Immune checkpoint inhibitors
- From:
Chinese Journal of Radiation Oncology
2024;33(7):673-677
- CountryChina
- Language:Chinese
-
Abstract:
The treatment of advanced malignant tumors usually includes chemotherapy, radiotherapy, immunotherapy and targeted therapy, etc. However, a single treatment often faces problems such as drug resistance, toxicity and side effects. Consequently, it is urgent to seek new methods. In 2015, Siwen Hu-Lieskovan proposed "oncology cocktail therapy" firstly. Cocktail therapy is the integration of three or more different methods to exert a synergistic anti-tumor effect. In recent years, many researchers have applied cocktail therapy in basic and clinical researches. For example, the combination of chemotherapy drugs, targeted drugs and immunotherapy drugs makes the advantages of drugs complementary. The combination of hyperthermia, chemotherapy and immunotherapy can improve the tumor immunosuppressive microenvironment and stimulate immunity, and then combines with anti-programmed death receptor 1 (aPD-1) drugs to produce synergistic effects. The results show that cocktail therapy can improve the efficacy and prognosis of advanced cancer patients. In this article, the role and impact of cocktail therapy were reviewed, aiming to provide reference for in-depth exploration of new combined treatments for advanced malignant tumors.
