Meta-analysis of comparison of efficacies between low-dose and standard-dose radiotherapy in human papillomavirus-associated oropharyngeal cancer
10.3760/cma.j.cn113030-20230913-00090
- VernacularTitle:HPV阳性口咽癌低剂量与标准剂量放疗疗效比较的meta分析
- Author:
Jiewen HAO
1
;
Shuxin WEN
;
Li ZHANG
;
Chen WANG
;
Shuntu CHE
;
Junlong LI
;
Meifang LUO
Author Information
1. 山西医科大学第三医院（山西白求恩医院 山西医学科学院 同济山西医院）耳鼻咽喉头颈外科，太原030032
- Keywords:
Oropharyngeal neoplasms;
Human papillomavirus;
Radiotherapy;
Low dose;
Meta-analysis
- From:
Chinese Journal of Radiation Oncology
2024;33(7):599-605
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the efficacy and safety of low-dose and standard-dose radiotherapy (LD-RT vs. SD-RT) in the treatment of oropharyngeal cancer patients with positive human papillomavirus (HPV). Methods:All comparative studies of low-dose versus standard-dose radiotherapy in the treatment of HPV-positive oropharyngeal cancer were searched from PubMed, Web of Science, Cochrane Library, EMbase, Chinese Biomedical Literature Database (CBM), CNKI, Chongqing VIP, and Wanfang databases from January 1, 2000 to February 9, 2023. According to the inclusion and exclusion criteria, the data were strictly screened, and the RevMan 5.4 software was used for meta-analysis.Results:A total of 8 studies were included. The pooled results showed that the overall survival (OS) and progression-free survival (PFS) of patients in the LD-RT group were similar to those in the SD-RT group ( HR=0.83, 95% CI=0.59-1.18, P=0.31; HR=0.97, 95% CI=0.53-1.78, P=0.92), but the rate of percutaneous endoscopic gastrostomy (PEG) insertion was significantly reduced ( RR=0.45, 95% CI=0.28-0.72, P=0.001). Conclusion:LD-RT yields similar efficacy and lower rate of PEG insertion compared with SD-RT in HPV-positive oropharyngeal neoplasm patients.
