Research on the beam delivery method of carbon ion beam FLASH irradiation experiment
10.3760/cma.j.cn113030-20230524-00126
- VernacularTitle:碳离子束FLASH照射实验束流配送方式的研究
- Author:
Zhiqiang LIU
1
;
Lirong ZHOU
;
Qiuning ZHANG
;
Jian SHI
;
Xiaohu WANG
Author Information
1. 兰州科近泰基新技术有限责任公司，兰州 730000
- Keywords:
Carbon ion beams;
FLASH treatment;
Synchrotrons;
Beam performance
- From:
Chinese Journal of Radiation Oncology
2024;33(6):548-553
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To perform FLASH irradiation experiments on cells and animals with carbon ion beams by updating the beam conditions and testing the performance of a clinical carbon ion therapy system.Methods:By using the vertical beam of the carbon ion therapy system and shortening the synchrotron beam extraction time to increase the current intensity, ultra-high dose rate beam could be achieved. Spreading the high current beam in the depth direction using a ridge filter and expanding it horizontally using point scanning technology could form the required field for cellular and animal experiments. The field flatness, penumbra, absorbed dose, average dose rate and other parameters were measured to verify whether the beam performance met the requirements.Results:The spread-out Bragg peak in the depth direction was consistent with the design, and the parameters such as field flatness and penumbra obtained by the measured lateral dose curve met the experimental requirements. After expansion, within a target volume of 20 mm×20 mm×10 mm, the absorbed dose in the field reaches 8 Gy, with the equivalent field dose rate of over 60 Gy/s and the maximum could reach 100 Gy/s. Within a target volume of 30 mm×30 mm×10 mm, the absorbed dose in the field is 4 Gy, and the equivalent filed dose rate of some energy in the field is greater than 40 Gy/s. In the experiment, the energy with a suitable dose rate can be selected for irradiation.Conclusion:After beam optimization, the carbon ion FLASH irradiation conditions for cytology and animal experiments can be realized on synchrotrons, and the beam performance parameters can meet the experimental requirements.
