Research progress in the effect of alternative splicing on radiosensitivity of cancer cells
10.3760/cma.j.cn113030-20230903-00082
- VernacularTitle:RNA选择性剪接对肿瘤细胞放射敏感性影响的研究进展
- Author:
Zifan QIN
1
;
Xiaoli ZHENG
;
Kangdong LIU
;
Hong GE
Author Information
1. 郑州大学附属肿瘤医院，河南省肿瘤医院放疗科，郑州 450008
- Keywords:
Alternative splicing;
Splicing variants;
Radiosensitivity
- From:
Chinese Journal of Radiation Oncology
2024;33(5):479-484
- CountryChina
- Language:Chinese
-
Abstract:
Radiation therapy is one of the most important treatment methods for malignant tumors. Radiosensitivity is the key factor affecting the therapeutic effect of radiation therapy for tumor patients, which has been a hot topic of research. Alternative splicing is a vital post-transcriptional regulatory step in the process of gene expression. It can produce a variety of different splicing isoforms of pre-mRNA, and then produce various proteins which play a crucial role in maintaining normal life activities of the body. Compared with normal cells, tumor cells have a higher proportion of splicing disorder events, which can lead to the occurrence of pathological processes such as genomic instability and angiogenesis, thus resulting in the progression of diseases. Abnormal splicing events occurring in tumors can be used as new therapeutic targets. In this article, RNA alternative splicing, splicing events affecting radiosensitivity, and the prospects were reviewed.
