Measurement of external radiation levels around patients treated with 177Lu-DOTA-TATE and preliminary estimation of doses to the surrounding personnel
10.3760/cma.j.cn112271-20240725-00278
- VernacularTitle:接受 177Lu-奥曲肽治疗患者体外辐射水平的检测及其所致周围人员剂量的初步估算
- Author:
Yongxiang PAN
1
;
Lixin DING
;
Feng WANG
;
Zhi YANG
Author Information
1. 北京大学肿瘤医院暨北京市肿瘤防治研究所核医学科 国家药监局放射性药物研究与评价重点实验室 北京市核医学质量控制和改进中心 恶性肿瘤发病机制及转化研究教育部重点实验室，北京 100142
- Keywords:
177Lu-DOTA-TATE;
Neuroendocrine tumors;
External irradiation;
Radiation dose
- From:
Chinese Journal of Radiological Medicine and Protection
2024;44(9):783-788
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the decay law of 177Lu-DOTA-TATE in the treatment of neuroendocrine tumors in patients with external radiation and the radiation dose to the surrounding persons. Methods:The radiation dose rate from patients to the surrounding environment after 177Lu-DOTA-TATE treatment was measured using a handheld radiation dosimeter at different times. The decay law of the radiation dose rate with time and distance was analyzed, and the radiation levels at different distances from the patients and the radiation dose of the patients to the surrounding persons were estimated. Results:The external radiation dose rate from the patients decayed exponentially with time rapidly in the early stage and gradually slowly in the later stage. The effective half-life was (1.41±0.25) h (0.9-1.8)h in the rapid decay stage and (40.18±6.0) h (32.7-54.73 h) in the slower decay stage. At 0 h after injection, the normalized mean radiation dose rates at 0.25, 0.5, 1, 2, and 3 m away from the patient were 41.7±6.3, 20.0±3.0, 7.2±3.8, 3.4±0.9, and 1.9±0.4 μSv·h -1·GBq -1, respectively. The radiation doses to doctors, nurses, physicists, and positioning technicians were 2.0, 10.24, 1.08, and 4.05 μSv/patient, respectively. Conclusions:The external radiation dose rate from patients receiving 177Lu-DOTA-TATE treatment rapidly decreases over time and distance. The radiation levels that patients may cause to the surrounding workers are within the allowable range of national standards. After discharge, patients should reduce close and long-term contact with the surrounding persons.
