Distribution of brain metastases from adenocarcinoma and non-adenocarcinoma among non-small cell lung cancer
10.3760/cma.j.cn112271-20240122-00028
- VernacularTitle:非小细胞肺癌中腺癌与非腺癌的脑转移位置分布研究
- Author:
Wei CHEN
1
;
Fenglei DU
;
Guoping ZUO
;
Kaiqiang CHEN
;
Guoping SHAN
Author Information
1. 南华大学核科学技术学院，衡阳 421001
- Keywords:
Non-small cell lung cancer (NSCLC);
Adenocarcinoma;
Non-adenocarcinoma;
Brain metastasis;
Spatial distribution
- From:
Chinese Journal of Radiological Medicine and Protection
2024;44(9):758-763
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the differences in the spatial distributions of brain metastases (BMs) from adenocarcinoma and non-adenocarcinoma among non-small cell lung cancer (NSCLS), aiming to provide a reference for developing optimal treatment protocols.Methods:A retrospective analysis was performed on data from 283 patients with NSCLC who underwent radiotherapy at the Zhejiang Cancer Hospital from January 2020 to July 2023. These patients included 191 adenocarcinoma cases with an average age of 62.04 years and 92 non-adenocarcinoma cases with an average age of 63.85 years. CT images with detected BMs of these patients were synchronously deformed and registered into a standard brain template to determine the distribution of BMs in the template. The Dice coefficient was employed to analyze the similarity in the distribution of BMs from adenocarcinoma and non-adenocarcinoma, and two-sample t-test was performed respectively using SPM and Dpabi software to ensure the consistency of the result. For brain regions with the number of BMs greater than or equal to 4, the voxels with a size 2 mm × 2 mm × 2 mm were counted. Results:Non-adenocarcinoma tended to invade the posterior lobe of the cerebellum, precuneus, anterior lobe of the cerebellum, cuneus, middle occipital gyrus, and middle temporal gyrus, with corresponding voxel counts of 2 577, 2 291, 1 947, 1 550, 1 200, and 600, respectively. In contrast, adenocarcinoma was more commonly metastasized to the inferior parietal lobule, posterior lobe of the cerebellum, central frontal gyrus, precentral gyrus, middle temporal gyrus, and precuneus, with the corresponding voxel counts of 211, 201, 194, 186, 137, and 84, respectively.Conclusion:Brain metastases exhibit different distributions between adenocarcinoma and non-adenocarcinoma, and both subtypes prefer to invade specific brain regions.
