Research progress on the ionizing radiation-induced mutational signatures
10.3760/cma.j.cn112271-20231123-00185
- VernacularTitle:电离辐射诱导的突变签名研究进展
- Author:
Ting WANG
1
;
Sutong YU
;
Jie LI
;
Yihan GUO
;
Jiahua YU
Author Information
1. 苏州大学苏州医学院放射医学与防护学院 放射医学与辐射防护国家重点实验室 江苏高校放射医学协同创新中心，苏州 215123
- Keywords:
Ionizing radiation;
Mutation;
Mutational signature;
Tumor
- From:
Chinese Journal of Radiological Medicine and Protection
2024;44(7):628-632
- CountryChina
- Language:Chinese
-
Abstract:
In the past decade, high-throughput sequencing technologies have generated a massive amount of genomic mutation data. The interpretation of mutation data from tumor samples has revealed mutational features highly associated with carcinogenic factors, which are referred to as mutational signatures. These mutational signatures enable the assessment of the contribution rates of various carcinogenic factors during the multi-stage development of tumors. Ionizing radiation-induced gene mutations constitute the molecular basis for its carcinogenic effects. Clarifying the patterns of mutational signatures induced by ionizing radiation is of great importance for a profound understanding of stochastic effects. This review presents the research history and analytical method of mutational signatures as well as a comprehensive summary of the current status of research on mutational signatures induced by ionizing radiation. The future development of this field is also discussed.
