Advances in application of organoids to research on radiotherapy of tumors
10.3760/cma.j.cn112271-20231103-00158
- VernacularTitle:类器官在肿瘤放射治疗相关研究中的应用进展
- Author:
Liang CHEN
1
;
Yiyin LIANG
;
Weiwei ZHANG
;
Jiaojiao TONG
;
Huojun ZHANG
Author Information
1. 海军军医大学附属长海医院放射治疗科，上海 200433
- Keywords:
Organoids;
Radiotherapy;
Experimental model;
Personalized therapy;
Radiotherapy sensitization
- From:
Chinese Journal of Radiological Medicine and Protection
2024;44(6):543-548
- CountryChina
- Language:Chinese
-
Abstract:
Organoids are in vitro-cultured three-dimensional (3D) miniature structures derived from human pluripotent stem cells or adult stem cells from healthy individuals or patients. Compared to traditional two-dimensional (2D) cell lines or animal models, organoids are regarded as more promising high-fidelity models, possessing unique advantages in terms of disease modeling, drug development, the establishment of living biobanks, and the exploration of personalized treatment. Over recent years, the rapid development of organoid technology has brought new hopes for innovating preclinical experimental tumor models and promoting clinical personalized diagnosis and treatment. This review is intended to introduce the development status and latest progress of organoids in the field of radiotherapy for tumors, explore the advantages and limitations of organoid models for cancer, and prospect for its application in the field of radiotherapy.
