Role and research progress of snoRNAs in ionizing radiation-induced DNA damage

VernacularTitle:snoRNA在电离辐射诱导的DNA损伤中的作用及研究进展
Author: Jiarong DENG ¹ ; Wencheng ZHANG ; Liping SHEN ; Zhidong WANG
Author Information

1. 南华大学衡阳医学院军事科学院研究生协作培养基地，衡阳　421001
Keywords: Small nucleolus RNA; Ionizing radiation; DNA damage response
From: Chinese Journal of Radiological Medicine and Protection 2024;44(5):450-455
CountryChina
Language:Chinese
Abstract: Small nucleolar RNAs (snoRNAs), a type of non-coding RNAs ubiquitous in eukaryotes, can be categorized into two types based on structural characteristics: box C/D snoRNAs and box H/ACA snoRNAs, which mediate the RNA modification of 2′-O-methylation and pseudouridylation, respectively. Recent studies have found that snoRNAs also affect the alternative splicing of mRNA precursors (pre-mRNA), mediate gene silencing by generating miRNA, and interact with proteins to regulate their functional activity. The process of DNA damage and repair always serves as a pivotal biological basis in research on the biological effects of ionizing radiation. Currently, there are rather limited studies on the role of snoRNAs in ionizing radiation-induced DNA damage. Thus, this paper reviews the biological functions of snoRNAs and their potential role in the regulatory repair of ionizing radiation-induced DNA damage, with a view to providing new ideas for exploring the function and mechanism of snoRNAs.