Amide proton transfer weighted imaging in assessment of acid-base metabolism in chronic ischemic brain tissue
10.3760/cma.j.cn112149-20240312-00121
- VernacularTitle:酰胺质子转移加权成像评估慢性缺血性脑组织酸碱代谢水平
- Author:
Hongxia LI
1
;
Chao XIA
;
Jiaxin ZENG
;
Zhiqin LIU
;
Xia WEI
;
Yuan SUN
;
Xing LI
;
Ziyu LI
;
Yue LI
;
Anqi XIAO
;
Yi LIU
;
Kai AI
;
Su LYU
;
Na HU
Author Information
1. 四川大学华西医院放射科 功能与分子影像四川省重点实验室 华西磁共振研究中心，成都 610041
- Keywords:
Magnetic resonance imaging;
Chronic ischemic cerebrovascular disease;
Amide proton transfer weighted imaging;
Cerebral perfusion
- From:
Chinese Journal of Radiology
2024;58(8):807-812
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore changes of acid-base metabolism in the brain tissue of patients with chronic ischemic cerebrovascular disease (CICVD) using MRI amide proton transfer-weighted (APTw) imaging.Methods:This was a cross-sectional study. From January 2021 to July 2022, thirty-nine patients with CICVD at West China Hospital, Sichuan University were retrospectively included. All patients received CT perfusion (CTP) and APTw imaging. NeuBrainCARE brain perfusion software was used to analyze the impaired perfusion sites and measure the mean transit time (MTT) and time to peak (TTP). Standard spatial matching between CTP and APTw images was performed to measure the APTw values of the same sites. For comparison with normal tissue, APTw values were measured for normal-appearing white matter (NAWM) in the ipsilateral cerebral hemisphere, the contralateral cerebral hemisphere, and the ipsilateral cerebellar hemisphere in areas of impaired perfusion. ANOVA was used to compare the APTw values of impaired perfusion brain tissue, ipsilateral cerebral NAWM, contralateral cerebral NAWM, and ipsilateral cerebellar NAWM. The Bonferroni method was used to correct for multiple comparisons. Pearson correlation coefficient was used to analyze the correlation between APTw values and MTT and TTP in the cerebral tissue with impaired perfusion.Results:In 39 patients with CICVD, both the mean and minimum APTw values of cerebral tissue with impaired perfusion were significantly lower than those in the NAWM of the ipsilateral cerebral hemisphere, the contralateral cerebral hemisphere, and the ipsilateral cerebellar hemisphere ( P<0.001). In the NAWM of the cerebellar hemispheres with unimpaired perfusion, both the mean and minimum APTw values were significantly higher than those in the ipsilateral cerebral hemispheres and the contralateral cerebral hemisphere ( P<0.001). Correlation analysis showed that MTT was significantly negatively correlated with both the mean APTw and the minimum APTw ( r values were -0.90 and -0.82, P<0.001). TTP was significantly negatively correlated with both the mean APTw and the minimum APTw ( r values were -0.86 and -0.78, P<0.001). Conclusion:APTw value can reflect acidosis in cerebral tissue with impaired perfusion in patients with CICVD.
