Value of intravoxel incoherent motion diffusion-weighted imaging quantitative parameters in different regions of kidney in the diagnosis of IgA nephropathy
10.3760/cma.j.cn112149-20231217-00477
- VernacularTitle:肾脏不同区域体素内不相干运动扩散加权成像定量参数诊断IgA肾病的价值
- Author:
Xue ZHAI
1
;
Pu CHEN
;
Shaopeng ZHOU
;
Xu BAI
;
Jian ZHAO
;
Yong WANG
;
Li ZHANG
;
Guangyan CAI
;
Song WANG
;
Haiyi WANG
Author Information
1. 解放军总医院第一医学中心放射诊断科，北京 100853
- Keywords:
Glomerulonephritis, IgA;
Magnetic resonance imaging;
Intravoxel incoherent motion diffusion-weighted imaging
- From:
Chinese Journal of Radiology
2024;58(6):640-646
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the value of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) parameters in different regions of the kidney in distinguishing IgA nephropathy (IgAN) patients from healthy volunteers.Methods:This study was a cross-sectional study. Eighty-four patients diagnosed with IgAN (IgAN group) who underwent renal biopsy (lower pole of the left kidney) and were pathologically confirmed at the First Medical Center of PLA General Hospital from February 2022 to September 2023 and thirty-four healthy volunteers (control group) were included prospectively. The regions of interest were outlined in the right renal cortex, medulla, and parenchyma for all subjects, and the apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudo-diffusion coefficient (D *), and perfusion fraction (f) were measured in the corresponding regions. The differences in IVIM-DWI parameters between the IgAN group and the control group were compared using the student′s t-test or the Mann-Whitney U test. Receiver operating characteristic curve analysis was performed on the parameters with statistically significant differences, and the area under the curve (AUC) was calculated. Results:There were statistically significant differences in renal cortical ADC, renal parenchymal ADC, renal cortical D, renal parenchymal D, and renal medullary f values between the IgAN group and the control group ( Z=-3.03, -2.21, -2.62, -2.03, -2.03; P=0.002, 0.027, 0.009, 0.043, 0.042). The AUCs (95% CI) for diagnosing IgAN using renal cortical ADC, renal parenchymal ADC, renal cortical D, renal parenchymal D, and renal medullary f values were 0.679 (0.586-0.762), 0.630 (0.537-0.717), 0.654 (0.535-0.774), 0.619 (0.497-0.742), and 0.620 (0.495-0.745), respectively. There were no statistically significant differences in renal medullary ADC, D, renal cortex, medulla and parenchyma D *, renal cortical and renal parenchymal f values between the two groups ( P>0.05). Conclusion:The quantitative parameters of renal IVIM-DWI are influenced by different measurement regions, among which the ADC, D of renal cortex and parenchyma, and f of renal medulla can be used for the initial diagnosis of IgAN.
