Causal association between inflammatory cytokines and fibromyalgia: a bidirectional Mendelian randomization analysis study
10.3760/cma.j.cn141217-20231221-00182
- VernacularTitle:基于双向孟德尔随机化分析炎性细胞因子与纤维肌痛症的因果关联研究
- Author:
Jiyao LIANG
1
;
Zehong LIN
;
Yan LU
;
Xinyu HE
;
Liangpu LIU
;
Jihu WEI
;
Honghai ZHOU
Author Information
1. 广西中医药大学研究生院，南宁 530001
- Keywords:
Mendelian randomization analysis;
Fibromyalgia;
Cytokines
- From:
Chinese Journal of Rheumatology
2024;28(7):478-483
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the causal association between inflammatory cytokines and fibromyalgia by Mendelian randomization analysis.Methods:By mining the GWAS Catalog database and FinnGen database, the exposure factor was set as inflammatory cytokines, and the outcome was fibromyalgia. The main analysis method adopted in this study is inverse variance weighted (IVW) method, with MR-Egger, Simple Mode method, weighted median (WM), and Weighted Mode as supplementary statistical methods for Mendelian randomization analysis. Subsequently, by swapping the exposure factors and outcomes, the directionality of the analysis was tested.Results:Among the 91 known inflammatory cytokines, a causal association was found between natural killer cell receptor 2B4 (CD244), monocyte chemotactic protein 2 (MCP-2), C-X-C chemokine 6 (CXCL6), interleukin 12β subunit (IL12B), and fibromyalgia. Among them, CD244, CXCL6, and IL12B were positively correlated with FM [CD244: OR(95% CI)=1.21(1.08, 1.35), P<0.001]. [MCP-2: OR(95% CI)=0.91(0.87, 0.96), P<0.001], [CXCL6: OR(95% CI)=1.15(1.06, 1.24), P<0.001], IL-12B [ OR(95% CI)=1.13(1.06, 1.20), P<0.001]. Sensitivity analysis did not find multiple effects, heterogeneity,or correlation. Conclusion:The increase in the levels of CD244, CXCL6, and IL-12B will increase the risk of FM, while the increase in the level of MCP-2 will reduce the risk of FM disease.
