The clinical characteristics of multiple sclerosis patients with positive anti-SSA antibody
10.3760/cma.j.cn141217-20230114-00015
- VernacularTitle:合并抗SSA抗体阳性的多发性硬化患者临床特点
- Author:
Xiaoyu CAO
1
;
Juan GUO
;
Yaran YANG
;
Zhibo YU
;
Wei ZHOU
Author Information
1. 首都医科大学附属北京天坛医院风湿免疫科，100070 北京
- Keywords:
Multiple sclerosis;
Sj?gren′s syndrome;
Anti-SSA antibody
- From:
Chinese Journal of Rheumatology
2024;28(7):472-477
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical characteristics of multiple sclerosis (MS) patients with positive anti-SSA antibody.Methods:The data of patients with positive anti-SSA antibody hospitalized in Beijing Tiantan Hospital between December 2011 and May 2020 were retrieved. Patients who fulfilled the diagnosis of MS were enrolled. MS patients with negative anti-SSA antibody hospitalized in the same period were matched based on gender and age in a ratio of 1∶2. The clinical characteristics of MS patients with positive anti-SSA antibody and those with negative anti-SSA antibody were compared. We used SPSS 24.0 statistical software to perform data analysis. The Shapiro-Wilk test was used to determine whether continuous variables conform to a normal distribution. The group differences of non-normal distribution of measurement data were analyzed by Mann-Whitney U test. Fisher exact probability method was used to compare the group differences of categorical variables. P<0.05 was considered statistically significant.Results:There were 785 hospitalized patients with anti-SSA positivity. Among these, a total of 7 patients (0.89%) were diagnosed as MS. Fourteen MS patients with negative anti-SSA antibody were included with matched sex and age. There was a statistical significant difference in the frequency of positive antinuclear antibody (ANA)and anti-Ro-52 antibody between MS patients with positive anti-SSA antibody and those with negative anti-SSA (6/7 vs. 0/14, P<0.001; 4/7 vs. 0/14, P=0.006, respectively). No statistical significant difference in other clinical features was detected between the two groups (P>0.05).Conclusion:The frequency of ANA and anti-Ro-52 antibody positivity is significantly higher in MS patients with positive anti-SSA antibody. Our results suggest the presence of positive anti-SSA antibody has no affect on clinical features of MS. The relationship between MS and anti-SSA positivity may be incidently coexisted.
