Concomitant extragenital malformations of female reproductive tract anomalies: analysis of 444 cases in Peking Union Medical College Hospital
10.3760/cma.j.cn112141-20231008-00136
- VernacularTitle:女性生殖器官畸形的伴发畸形特点
- Author:
Si SU
1
;
Xinmiao BAO
;
Shu WANG
;
Na CHEN
;
Zhufeng LIU
;
Dawei SUN
;
Jinhua LENG
;
Qingbo FAN
;
Honghui SHI
;
Zhijing SUN
;
Juan CHEN
;
Haiyuan LIU
;
Xin YU
;
Junji ZHANG
;
Yi DAI
;
Jinghe LANG
;
Lan ZHU
Author Information
1. 中国医学科学院北京协和医学院北京协和医院妇产科 国家妇产疾病临床医学研究中心 疑难重症及罕见病全国重点实验室，北京 100730
- Keywords:
Abnormalities, multiple;
Genitalia, female;
Urogenital abnormalities;
Musculoskeletal abnormalities
- From:
Chinese Journal of Obstetrics and Gynecology
2024;59(5):346-352
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the incidence and clinical phenotype of the concomitant extragenital malformations in the patients with female reproductive tract anomalies.Methods:A retrospective study was conducted using clinical data of hospitalized patients diagnosed with uterine, cervical, or vaginal malformations from January 2003 to December 2022 in Peking Union Medical College Hospital. The malformations were classified according to American Society for Reproductive Medicine müllerian anomalies classification 2021, and in each type, the incidence and specific manifestations of concomitant extragnital malformations were analyzed.Results:A total of 444 patients were included. The overall incidence of concomitant extragenital malformations was 43.5% (193/444), including urinary system, skeletal system, and other system malformations. Renal malformations on the obstructed side were present in all patients with oblique vaginal septum syndrome (100.0%, 78/78). The total incidence of concomitant extragnital malformations was as high as 8/11 in uterus didelphys, 43.5% (10/23) in unicornuate uterus, 33.6% (79/235) in Mayer-Rokitansky-Küster-Hauser syndrome, 18.8% (6/32) in septate uterus and 18.5% (12/65) in cervical agenesis. Urinary system malformations (30.6%, 136/444) and skeletal system malformations (13.5%, 60/444) were the most common concomitant malformations in all types, in which, unilateral renal agenesis and scoliosis were the most common.Conclusions:Urinary and skeletal system malformations are important features of female reproductive tract anomalies. Urologic ultrasonography and spinal roentgenogram are recommended for all patients with female reproductive tract anomalies.
