Ultrasound evaluation of respiratory muscle involvement in children with Duchenne muscular dystrophy
10.3760/cma.j.cn131148-20240515-00286
- VernacularTitle:超声评价Duchenne肌营养不良呼吸肌受累改变
- Author:
Xuan ZHANG
1
;
Yun ZHANG
;
Shuang CHEN
;
Shiwen WU
;
Yanfeng SUN
;
Faqin LYU
;
Haiyan KOU
Author Information
1. 解放军总医院第三医学中心超声科，北京 100039
- Keywords:
Ultrasonography;
Duchenne muscular dystrophy;
Diaphragm;
Intercostal muscle;
Gray value
- From:
Chinese Journal of Ultrasonography
2024;33(11):930-934
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the ultrasonographic manifestations of intercostal muscle and diaphragm involvement in Duchenne muscular dystrophy (DMD) and their correlations with functional status, and to explore the pattern of muscle damage in patients with DMD and the potential role of ultrasonography in assessing disease progression.Methods:A total of 28 patients with DMD who received treatment in the Third Medical Centre of PLA General Hospital from May to December 2023 were prospectively collected as DMD group, and 28 healthy children matched in age and sex were included as controls for a prospective study.Diaphragm thickening fraction (DTF) and intercostal muscle thickening fraction (ICMTF) were measured by B-mode and M-mode ultrasonography, and the muscle gray values were recorded. The differences between groups were compared, and the values of DTF and ICMTF in evaluating the structural and functional changes of respiratory muscle were analyzed.Results:Compared with the control group, the gray value of respiratory muscle was significantly decreased in DMD group, the diaphragm and intercostal muscle were significantly thickened at the end of inspiratory and expiratory periods, DTF was significantly decreased, and ICMTF was significantly increased (all P<0.001). Conclusions:Ultrasound can evaluate the structural changes of respiratory muscle in DMD, so as to clarify the relationship between the structure and function of respiratory muscle in DMD patients.
