Value of contrast-enhanced ultrasound combined with transvaginal ultrasound in predicting high-risk endometrial cancer
10.3760/cma.j.cn131148-20231219-00302
- VernacularTitle:超声造影联合经阴道超声预测高危子宫内膜癌的价值
- Author:
Dongmei LIU
1
;
Min YANG
;
Xiaoning GU
;
Fang LIU
;
Fuwen SHI
;
Zhenzhen CHENG
;
Meng HAN
;
Yong LIU
Author Information
1. 首都医科大学附属北京世纪坛医院超声科，北京 100038
- Keywords:
Contrast-enhanced ultrasound;
Endometrial cancer;
Ultrasonography, transvaginal
- From:
Chinese Journal of Ultrasonography
2024;33(5):392-398
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the application value of contrast-enhanced ultrasound (CEUS) combined with transvaginal ultrasound features and quantitative parameters in evaluating high-risk endometrial cancer (EC).Methods:Retrospective analysis was made on 69 EC patients who received CEUS examination and were confirmed by surgery and pathology in Beijing Shijitan Hospital, Capital Medical University from December 2017 to September 2022. According to postoperative pathology, the patients were divided into low-risk group ( n=38) and high-risk group ( n=31). The differences in CEUS, transvaginal ultrasound features and quantitative parameters between the two groups were compared, relevant parameters that with predictive value for high-risk EC were screened, and these parameters were scored. Results:①There were differences in lesion size (thick diameter, long diameter), vascular morphology, and color blood flow score between high and low risk ECs (all P<0.05). ②There were differences in CEUS parameters [perfusion mode, enhancement intensity, area under curve(AUC)] between high and low risk EC groups (all P<0.05). ③The areas under the ROC curve for diagnosing high-risk EC were 0.79, 0.69, 0.69, and 0.62, respectively, based on the critical values of lesion thickness diameter ≥1.85 cm, lesion length diameter ≥2.05 cm, ultrasound contrast quantification parameter AUC ≥859 au, and enhancement intensity ≥29.4 dB. ④Using statistically significant parameters for scoring, the sensitivity and specificity for diagnosing high-risk EC with the score ≥5, were 70.97% and 89.47%, respectively. Conclusions:The combination of CEUS and transvaginal ultrasound is a feasible method for predicting high-risk EC. CEUS parameters (enhanced intensity, AUC, and " focal" perfusion mode) are related to high-risk EC. The combination of CEUS and transvaginal ultrasound helps to pre-evaluate the pathological prognostic factors of endometrial malignant lesions before surgery, providing a basis for clinical follow-up treatment.
