Preliminary study on the diagnostic efficacy of contrast-enhanced ultrasound in breast solid ductal papilloma
10.3760/cma.j.cn131148-20231221-00307
- VernacularTitle:超声造影对乳腺实性导管内乳头状瘤诊断效能的初步研究
- Author:
Lizhu HOU
1
;
Yan ZHENG
;
Ying SONG
;
Mengqi ZHOU
;
Lin ZHU
;
Dan ZHAO
;
Wei WANG
;
Fenglin DONG
Author Information
1. 苏州大学附属第一医院超声科，苏州 215006
- Keywords:
Contrast-enhanced ultrasound;
Intraductal papilloma;
Fibroadenoma;
Enhancement sequence;
Logistic regression;
Diagnostic efficacy
- From:
Chinese Journal of Ultrasonography
2024;33(5):378-384
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the value of contrast-enhanced ultrasound (CEUS) in the diagnosis of solid intraductal papilloma (sIDP) of breast by comparing with fibronenoma of breast (FA).Methods:The CEUS data of 62 cases of sIDP patients and 94 cases of FA patients that confirmed by pathology in the First Affiliated Hospital of Soochow University from October 2016 to January 2021 were retrospectively analyzed. The patients were divided into sIDP group and FA group according to the pathological results. The enhancement speed, enhancement degree, enhancement uniformity, whether the edge after enhancement was polished, whether the enhancement range was enlarged, whether there was a ring unenhanced area in the inner edge of the lesion and whether the inner edge of the unenhanced area was polished were observed in the two groups. SonoLiver software was used to perform offline analysis of the dynamic process of CEUS in the two groups respectively, the enhancement sequence diagram of the lesions was obtained. The pathological result was taken as the gold standard, univariate analysis was applied, and the parameters with statistical significance between the two groups were included in multivariate Logistic regression analysis to establish a differential diagnosis model. The diagnostic efficiency of sIDP was analyzed by ROC curve and diagnostic model.Results:Compared with the FA group, CEUS in the sIDP group mostly showed fast forward, high enhancement, and the enhancement sequence was mostly centrifugal. After CEUS, the lesion edges in the sIDP group were mostly accompanied by unenhanced areas and the inner edges of the unenhanced areas were not intact, and the differences between the two groups were statistically significant (all P<0.05). Binary Logistic regression showed that age, enhancement degree and enhancement order were independent risk factors for sIDP diagnosis. The ROC curve showed that the area under the ROC curve of age, enhancement degree and enhancement sequence combined for the diagnosis of sIDP was 0.874 (95% CI=0.812-0.922), the accuracy was 76.9%, the sensitivity was 67.7%, the specificity was 83.0%, the positive predictive value was 72.4%, and the negative predictive value was 79.6%. Conclusions:There are significant differences in age, enhancement degree and enhancement sequence between sIDP and FA patients. The three-parameter combination can improve the diagnostic efficiency of sIDP.
