Approaches in vascularization of tissue-engineered bone and their research progress
10.3760/cma.j.cn115530-20240705-00280
- VernacularTitle:组织工程骨血管化的构建方法及研究进展
- Author:
Yulei WANG
1
;
Jingyuan LI
;
Nengqi SHAO
;
Wenhao XU
;
Fanzhe FENG
;
Zhijun CAI
;
Zhongzheng YU
;
Xiaoqing HE
;
Yongqing XU
;
Yi CUI
Author Information
1. 大理大学临床医学院，大理 671000
- Keywords:
Osteogenesis;
Tissue engineering;
Neovascularization;
Bone defects
- From:
Chinese Journal of Orthopaedic Trauma
2024;26(10):915-920
- CountryChina
- Language:Chinese
-
Abstract:
Tissue engineering bone technology, grounded in seed cells, cytokines, and scaffold supports, provides an effective solution for addressing extensive bone defects, demonstrating significant potentials in the field of bone repair. However, this technology still faces numerous challenges. Focusing on vascularization in engineered bones, this article reviews various methods to enhance vascularization within tissue-engineered bones, including multicellular co-culture, application of angiogenic factors, advanced 3D printing, and aid of surgical interventions. This article also analyses the latest research developments and the limitations of the methods, and speculates future research directions for tissue engineered bone.
