Mechanism of the mechanosensitive channel Piezo1 regulating chondrocytes in post-traumatic osteoarthritis: a review

VernacularTitle:机械敏感通道Piezo1对创伤性关节炎软骨细胞调控机制的研究进展
Author: Gongwu YUAN ¹ ; Zhigang LI ; Xi KE ; Ximing LIU
Author Information

1. 湖北省中西医结合医院骨科，武汉　430015
Keywords: Osteoarthritis; Ion channels; Chondrocytes; Stress, mechanical
From: Chinese Journal of Trauma 2024;40(11):1040-1048
CountryChina
Language:Chinese
Abstract: Post-traumatic osteoarthritis (PTOA) is a chronic degenerative joint disease caused by joint injury and abnormal mechanical stress stimulation is one of its key mechanisms. Currently, it is difficult to repair the articular cartilage completely even with surgical treatment and there is a lack of effective treatments for PTOA. Chondrocytes, one of the primary cell types involved in the pathogenic process of PTOA, are highly sensitive to mechanical signals. The mechanosensitive ion channel Piezo1 serves the important functions of sensing external forces and mechanical stimuli and plays a crucial role in PTOA by regulating chondrocytes′ responses to mechanical stress. Therefore, its essential to understand the mechanisms of the Piezo1 channel in regulating PTOA chondrocytes in exploring new therapeutic strategies. To this end, the authors reviewed the research progress on the regulatory mechanisms of the Piezo1 channel on PTOA chondrocytes, aiming to provide a reference for future studies on PTOA mechanisms and treatment options.