Expert consensus on the construction, evaluation and application of bone organoids (version 2024)
- VernacularTitle:骨类器官的构建、评价与应用专家共识（2024版）
- Author:
Jian WANG
1
;
Long BAI
;
Xiao CHEN
;
Yuanyuan LIU
;
Guohui LIU
;
Zhongmin SHI
;
Kaili LIN
;
Chuanglong HE
;
Jing WANG
;
Zhen GENG
;
Weiyang SHI
;
Wencai ZHANG
;
Fengjin ZHOU
;
Qiang YANG
;
Lili YANG
;
Zhiwei WANG
;
Haodong LIN
;
Yunfei ZHANG
;
Fuxin WEI
;
Wei CHEN
;
Wenguo CUI
;
Fei LUO
;
Jun FEI
;
Hui XIE
;
Jian LUO
;
Chengtie WU
;
Xuanyong LIU
;
Yufeng ZHENG
;
Changsheng LIU
;
Jiacan SU
Author Information
- Keywords: Bone diseases; Organoids; Stem cells; Ethics
- From: Chinese Journal of Trauma 2024;40(11):974-986
- CountryChina
- Language:Chinese
- Abstract: Bone organoids can simulate the complex structure and function of the bone tissues, which makes them a frontier technology in organoid researches. Bone organoids show a tremendous potential of applications in bone disease modeling, bone injury repair, and medicine screening. Although advancements have been made so far in constructing bone organoids with functional structures like mineralization, bone marrow, trabecular bone, callus, woven bone, etc, the researches in this field are confronted with numerous challenges such as lack of standardized construction strategies and unified evaluation criteria, which limits their further promotion and application. To standardize researches in bone organoids, the Orthopedic Expert Committee of Geriatric Branch of Chinese Association of Gerontology and Geriatrics, the Youth Osteoporosis Group of Orthopedic Branch of Chinese Medical Association, the Osteoporosis Group of Orthopedic Surgeon Branch of Chinese Medical Doctor Association, and the Osteoporosis Committee of Shanghai Association of Integrated Traditional Chinese and Western Medicine organized related experts to formulate Expert consensus on the construction, evaluation, and application of bone organoids ( version 2024) based on an evidence-based approach. A total of 17 recommendations were put forth, aiming to standardize researches and clinical applications of bone organoids and enhance their value in scientific research and clinical practice.
