Preconditioning strategies for mesenchymal stem cells and their application in repair of spinal cord injury: a review
10.3760/cma.j.cn501098-20240322-00234
- VernacularTitle:间充质干细胞预处理策略及其在脊髓损伤修复中应用的研究进展
- Author:
Zhengchao WU
1
;
Heng WANG
;
Yang LU
;
Cheng CHEN
;
Xiaoqing CHEN
Author Information
1. 南通大学附属医院脊柱外科，南通大学医学院，南通 226001
- Keywords:
Spinal cord injuries;
Mesenchymal stem cell transplantation;
Preconditioning
- From:
Chinese Journal of Trauma
2024;40(9):850-857
- CountryChina
- Language:Chinese
-
Abstract:
Spinal cord injury is a severe central nervous system injury that may result in partial or complete loss of sensory and motor function. Its treatment methods include laminotomy decompression, high-dose intravenous injection of methylprednisolone, etc., but their efficacy is not satisfactory. Mesenchymal stem cells (MSCs) are promising in treating spinal cord injury due to their plasticity, low immunogenicity, strong paracrine ability and multi-directional differentiation ability, but problems still exist such as low survival rate, low directional migration ability and unpredictable cell differentiation after transplantation. The strategies for preconditioning MSCs in vitro to enhance their efficacy through gene overexpression, stimulation by physicochemical factors, three-dimensional culture, and cell pre-differentiation have been applied in several studies upon repair of spinal cord injury, but there is no complete summary at present. The authors reviewed these preconditioning strategies for MSCs and the related research progress in spinal cord injury repair so as to provide a reference for the basic research and clinical treatment.
