Application of bacteriophage therapy in the antibacterial treatment for wound infections: a review
10.3760/cma.j.cn501098-20240329-00248
- VernacularTitle:噬菌体疗法在伤口感染抗菌治疗中应用的研究进展
- Author:
Lihuan REN
1
;
Jian SONG
;
Limei YIN
;
Xiuping DING
;
Fang DONG
;
Juju DIAO
;
Lulu ZHANG
;
Ani SUN
Author Information
1. 潍坊市人民医院感染管理办公室，潍坊 261000
- Keywords:
Wound infection;
Soft tissue infections;
Bacteriophage;
Drug resistance
- From:
Chinese Journal of Trauma
2024;40(9):844-849
- CountryChina
- Language:Chinese
-
Abstract:
Wound infections, secondary to acute and chronic wounds caused by mechanical, thermal, chemical factors, etc, not only delay wound healing but also may lead to mortality. The prolonged or inappropriate use of antibiotics lead to the growth of drug-resistant bacteria, resulting in refractory wound infections and poor treatment outcomes, which highlights the urgent need for effective therapies. Bacteriophages show great promise in treating drug-resistant wound infections due to their effectiveness in killing drug-resistant bacteria, their good resistance against bacterial biofilm (BBF) and their absence of cytotoxicity to eukaryotic cells. However, the mechanisms underlying bacteriophages′ resistance against BBF remain incompletely understood and their antibacterial efficacy for wound infections may also vary. For this purpose, the authors reviewed the biological characteristics and mechanisms of bacteriophages and their application in antibacterial therapies for wound infections, aiming to provide a reference for further research and application of bacteriophages in the treatment of wound infections.
