Correlation and role of intestinal microbiota in neurological complications after traumatic brain injury: a review
10.3760/cma.j.cn501098-20240514-00340
- VernacularTitle:肠道菌群在创伤性脑损伤神经系统并发症中的关系及作用的研究进展
- Author:
Lin LIU
1
;
Yanjun WANG
;
Linxiao WANG
;
Jiangang XIE
;
Meng ZHANG
;
Wen YIN
Author Information
1. 空军军医大学附属西京医院急诊科，西安 710001
- Keywords:
Brain injuries, complications;
Cranial nerve injuries;
Gastrointestinal tract;
Intestinal microbiota
- From:
Chinese Journal of Trauma
2024;40(9):837-843
- CountryChina
- Language:Chinese
-
Abstract:
Patients with traumatic brain injury (TBI) may develop neurological complications such as Alzheimer′s disease, stroke and epilepsy, which severely affect their quality of life. Currently, neurological complications after TBI are poorly understood and there are no comprehensive treatments or definitive interventions for them. Complex pathophysiological changes in the brain, systemic immunological responses, and gastrointestinal dysfunction after TBI all severely affect the biodiversity of the intestinal microbiota and related metabolites, which leads to intestinal dysbiosis and metabolic disorders and exert continued effects on the nervous system. Intestinal microbial probiotic flora that colonize in living organisms are a category of active microorganisms beneficial to the host and supplementation of intestinal probiotics can have a modulatory effect on the nervous system directly or indirectly. The targeted therapeutic effects of intestinal microbial probiotic flora on neurological complications after TBI and the intrinsic mechanism of the effects have not been comprehensively summarized currently. For this purpose, the authors reviewed the research progress on the effects of regulating intestinal microbial probiotic flora on post-TBI neurological complications so as to provide a reference for the clinical prevention and treatment of post-TBI neurological complications.
