Incidence and risk factors of pulmonary hypertension in Chinese people living with human immunodeficiency virus
10.3760/cma.j.cn311365-20230926-00095
- VernacularTitle:中国人类免疫缺陷病毒感染者的肺动脉高压发生情况及危险因素分析
- Author:
Ling LUO
1
;
Xiaojing SONG
;
Wei LYU
;
Zhengyin LIU
;
Huanling WANG
;
Yanling LI
;
Xiaoxia LI
;
Wei CAO
;
Taisheng LI
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院感染内科，北京 100730
- Keywords:
HIV;
Pulmonary hypertension;
Cardiac Doppler ultrasonography;
Anti-retroviral therapy
- From:
Chinese Journal of Infectious Diseases
2024;42(3):141-146
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate pulmonary hypertension (PH) in Chinese people living with human immunodeficiency virus (HIV) receiving long-term anti-retroviral therapy (ART) and those who had not received ART for HIV infection, and to analyze the risk factors for PH in HIV infected individuals, so as to provide evidence for the monitoring and management of cardiovascular diseases in people living with HIV in China.Methods:HIV infected individuals who received long-term ART were from the NCT04463810 study cohort. In addition, using propensity score matching method, gender matched HIV infected individuals who had not received ART were selected as controls from the NCT00872417 and NCT01844297 studies. This study was a retrospective and observational clinical study. Basic data, clinical visit and cardiac Doppler ultrasonography data were collected to analyze the prevalence of PH and risk factors for PH in people living with HIV. Chi-square test and multivariate logistic regression were used for statistical analysis.Results:Among the 318 HIV infected individuals, 159 underwent long-term ART and 159 did not receive ART, which were divided into long-term ART group and ART-na?ve group, respectively. Among 318 HIV infected individuals, 30 cases (9.4%) experienced PH, including 23 cases (7.2%) with critical PH, six cases (1.9%) with mild PH, one case (0.3%) with moderate PH, and there was no severe PH. The prevalence of PH in the long-term ART group was 5.0%(8/159), which was lower than that in the ART-na?ve group (13.8%, 22/159). The difference was statistically significant ( χ2=7.21, P=0.012). Multivariate analysis showed that older age (odds ratio ( OR)=1.064, 95% confidence interval ( CI) 1.019 to 1.111, P=0.016) and unsuppressed HIV status ( OR=2.660, 95% CI 1.041 to 6.797, P=0.041) were independent risk factors for PH of people living with HIV. Conclusions:The prevalence of PH in people living with HIV with long-term ART is lower than that of ART-na?ve people living with HIV. Older age and unsuppressed HIV status are independent risk factors for PH in people living with HIV. Cardiac Doppler ultrasonography is helpful for the early screening of PH in people living with HIV. ART should be actively performed to reduce the incidence of PH in people living with HIV.
