Protective Effect of Panax quinquefolium 20s-proto-panaxdiolsaponins on Acute Myocardial Infarction in Dogs
10.3321/j.issn:1001-5302.2001.06.021
- VernacularTitle:西洋参叶20s-原人参二醇组皂苷对犬急性心肌梗死的保护作用
- Author:
Da-Yuan SUI
1
;
Xiao-Feng YU
;
Shao-Chun QU
;
Zhong-Zhi LU
;
Li WANG
;
Man-Qiu CHEN
Author Information
1. Bethune Medical University
- From:
China Journal of Chinese Materia Medica
2001;26(6):416-419
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the protective effects of Panax quinquefolium 20s-protopanaxdiolsaponins extracted from leaves of P.quinquefolium（PQDS）on acute myocardial infarction（AMI）in dogs. Method：The parameters of myocardial infart size , the serum CK and LDH activity, myocardial metabolism,free radicals and coronary circulation etc were determined by using the model of ligation of LAD in the anaesthetized open-chest dogs. Result：In dogs treated with PQDS（in a dosage of 10 and 20 mg*kg-1 iv infusion），the myocardial infarct size, the activity of serum CK ,LDH and the contents of serum FFA and LPO were decreased，whereas the activity of serum SOD and GSH-Px increased markedly.At the same time, myocardial blood flow was increased and coronary vascular resistance decreasedsignificantly. Conclusion：PQDS has protective effect on myocardial ischemia by modifying metabolic dysfunction of FFA, inhibiting oxygen free radicalmediated peroxidation of membrane lipids ， enhancing endogenous antioxidase activity and increasing myocardial blood supply.
