Studies on Metabolism of Oxymatrine by Human Intestinal Bacteria
10.3321/j.issn:1001-5302.2001.04.018
- VernacularTitle:氧化苦参碱肠内菌代谢及吸收入血活性成分的研究
- Author:
Ming-Lei WANG
1
;
Ben-Xiang WANG
;
Qiu-Li ZHOU
Author Information
1. 长春中医学院
- From:
China Journal of Chinese Materia Medica
2001;26(4):272-274
- CountryChina
- Language:Chinese
-
Abstract:
Objective : To study the oxymatrine metabolism induced by human intestinal bacteria and its absorbed metabolites in blood. Method :TLC and HPLC were used to examine oxymatrine and its metabolites, and UV, IR, NMR and MS were used to confirm the chemical structures of the metabolites. Result: Oxymatrine was transformed into matrine by human intestinal bacteria metabolism in vitro. Rats were given orally oxymatrine 100 mg*kg-1 and were decapitated 3 hours after administration, and their blood was taken to examine serum metabolites by TLC and HPLC, which revealed that oxymatrine and matrine were absorbed into blood. Conclusion:Oxymatrine will be transformed into matrine when it is given orally and both of the alkaloids can be absorbed to blood.
