Protective Mechanism of Tianmacuzhi Granules in Brain
10.3321/j.issn:1001-5302.2001.04.017
- VernacularTitle:天麻促智颗粒的脑保护机制研究
- Author:
Chun-Yu CAO
1
;
Gui-You DU
;
Ping-Ping ZUO
;
Xian-Feng LIU
;
Wen-Tao WANG
;
Yong ZHAO
;
Xiu-Rong WANG
;
Hai-Feng CUI
Author Information
1. Institute of Chinese Materia Medica,China Academy of Traditional Chinese Medicine
- From:
China Journal of Chinese Materia Medica
2001;26(4):269-272
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To provide pharmacological evidence for the protective effects of Tianmacuzhi Granules (TMC) in mouse brain in a ischemia-reperfusion model. Method: Receptor binding test of NMDA receptor and M receptor in brain, GPx activity determination in brain and liver effected by different dose of TMC were performed. Result: TMC could reduce the NMDA receptor activitiy, increase the M receptor activity and GPx activity of cerebral cortex and hippocampus tissues significantly. Conclusion: TMC might antagonize ischemia-reperfusion injury of brain by reducing the glutamate neurotoxicity and increasing the function of cholinergic nerve and effects of anti-peroxidization in brain.
