Studies on Preparation of Herba EpimediiTotal Flavonoids Phyt osomes and Their Pharmaceutics
10.3321/j.issn:1001-5302.2001.02.010
- VernacularTitle:淫羊藿黄酮磷脂复合物的制备及其剂型研究
- Author:
Yong-Nan JIANG
1
;
Zi-Pei YU
;
Ze-Min YANG
;
Ji-Min CHEN
Author Information
1. Guangzhou Railway Central Hospital
- From:
China Journal of Chinese Materia Medica
2001;26(2):105-108
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To optimize preparation techniques for Herba E pimedii flavonoid phytosomes (EFP) and explore their suitable pharmaceutics. Methods: To optimize the preparation conditions by means of unifo rm design and step regression, prepare Herba Epimedii total flavonoid phytosomes by means of solvent evaporation and investigate the accumulative dissolution of different ratios of EFP-PVP precipitates by means of dissolution release. Resu lt: The optimized preparation conditions are as follows: solvent-tetrahydrofura n, lecithin to PVP-2.5 times, temperature-40 ℃ and reaction-3 hours. Oil/wa ter apparent partition coefficient of icariin was enhanced more than 4 times by phospholipid. The accumulative dissolution of Herba Epimedii flavonoids of EFP- PVP precipitate was significantly higher than that of its physical mixture and H erba Epimedii extract tablet. Conclusion: Phospholipid can ef fectively enhance the oil/water apparent partition coefficient of icariin, and P VP can improve the dissolution of Herba Epimedii phytocomes, but the pharmacokin etics needs further study.
