Effect of Xanthnotoxol on Contractility of Isolated Rabbit Ileum
10.3321/j.issn:1001-5302.2001.01.020
- VernacularTitle:花椒毒酚对家兔离体回肠的作用
- Author:
Xiao HU
1
;
Li ZHOU
;
Qi-Shen LIAN
;
Jing ZHENG
;
Jing-Ge YANG
;
Fei LAI
Author Information
1. Gannan Medecal College
- From:
China Journal of Chinese Materia Medica
2001;26(1):56-58
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effects of Xanthnotoxol on contractility of isolated rabbit ileum and its relationship with Ca2+. Method: Routime experimental methods for isolated ileum were adopted. Result: Xanthnotoxol (XT) and Verapamil (Ver) inhibited the contraction of iso lated rabbit ileum smoth muscle induced by submaximal concentrations of acetylcholine (ACh) and serotonim (5-TH), with a IC50 value (μmol*L-1) of 10.495±1.521,0.428±0.001and 18.132±1.627,0.249±0.003,respectively. XT and Ver inhibited the contraction induced by Ca2+after high K+ depolorization and for noncompetitively antagonist CaCl2 cumulative dose-response curve, the pD'2 value was 4.69±0.03 and 6.35±0.10, respectively. XT (10μmol*L-1)and Ver(0.06μmol*L-1)inhibited the contraction induced by ACh in Ca2+-free medium, while XT (100μmol*L-1)but not Ver(0.6μmol*L-1) inhibited the extracellar Ca2+-dependent contraction induced by ACh. Conclusion: XT has a calcium-antagonistic effect which was not similar to that of Ver.
