Effect of Tianma Cuzhi Keli (TMCZKL) on Contents of Transmitter Amino Acids of Brain Tissue in the Mouse Repetitious Cerebral Ischemia Reperfusion
10.3321/j.issn:1001-5302.2001.01.019
- VernacularTitle:天麻促智颗粒对反复脑缺血再灌小鼠脑组织递质性氨基酸含量的影响
- Author:
Jian-Hua FU
1
;
Gui-You DU
Author Information
1. 中国中医研究院中药研究所
- From:
China Journal of Chinese Materia Medica
2001;26(1):53-55
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To research the mechanism of protective action of TMCZKL on brain, Method: Contents of transmitter amino aclds in cortex and hippocampus befort and after administration of TMCZKL were measured in mice of repetifious cerebral ischemia reperfusion. Result: The three doses of TMCZKL raised the content of glutamic acid in cortex and hippocampus the content of aspartic acid in hippocampus and decreased GABA content in cortex significantly. Conclusion: TMCZKL might antagonize ischemic injury through regulating contents of transmitter amino acids and sustain the dynamic equilibrium of EAA and IAA.
