Clinical Study on the Treatment of Knee Osteoarthritis with Xiaoyusan Simplified Plaster
10.19879/j.cnki.1005-5304.202405001
- VernacularTitle:消瘀散精简方贴膏治疗膝骨关节炎临床研究
- Author:
Bitao MA
1
;
Ping BAI
;
Weiran TENG
;
Lilun JIN
Author Information
1. 上海交通大学医学院附属新华医院,上海 200092
- Keywords:
knee osteoarthritis;
cartilage metabolism;
Xiaoyusan simplified plaster
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2024;31(12):156-162
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of Xiaoyusan simplified plaster in the treatment of knee osteoarthritis and the significance of intervention in cartilage metabolism.Methods Totally 105 patients with knee osteoarthritis were divided into Xiaoyusan simplified prescription group,Xiaoyusan group and diclofenac diethylamine group according to random number table method.Xiaoyusan simplified prescription group:Apply it to the swollen and painful area,covering the entire lesion area,and change the dressing every 24 hours;Xiaoyusan group:Apply it to the swollen and painful area,covering the entire lesion area,and change the dressing every 24 hours;diclofenac diethylamine group:Apply evenly to the swollen and painful area,3 times a day;all the groups were treated for 2 courses(4 weeks).The changes of VAS score,WOMAC score,knee joint activity and the content of cartilage metabolism index HA,type Ⅱ collagen,COMP and CTX-Ⅱ before and after treatment were compared.Safety indicators of the three groups were monitored.Results The total effective rates of Xiaoyusan simplified plaster group and Xiaoyusan group were all over 97.1%(33/34),better than the diclofenac diethylamine group(81.8%,27/33),with statistical significance in the three groups(P<0.05).Xiaoyusan simplified plaster group and Xiaoyusan group were superior to diclofenac diethylamine group in VAS score,WOMAC score,sitting-standing 5 times time(P<0.05);Xiaoyusan simplified plaster group and Xiaoyusan group were superior to diclofenac diethylamine group in delaying the decrease of HA content and the increase of COMP content,with statistical significance(P<0.05).After treatment,there was no significant difference in VAS score,WOMAC score,knee joint activity and bone metabolism index content between Xiaoyusan simplified plaster group and Xiaoyusan group(P>0.05).The blood routine,urine routine,liver function,kidney function and electrocardiogram examinations before and after treatment in the three groups were all normal.Conclusion Xiaoyusan simplified plaster has the same efficacy as Xiaoyusan,which can reduce the pain of knee osteoarthritis patients,increase the knee joint activity and daily living ability of patients,and delay the cartilage injury metabolism.
