Exploration on the Medication Law of National TCM Master Gan Zuwang in Treating Rhinitis Based on Multivariate Data Mining
10.19879/j.cnki.1005-5304.202402324
- VernacularTitle:基于多元数据挖掘探讨国医大师干祖望治疗鼻炎的用药规律
- Author:
Yue LI
1
,
2
;
Hailan HONG
;
Wenlin LI
Author Information
1. 南京中医药大学人工智能与信息技术学院,江苏 南京 210023
2. 江苏省智慧中医药健康服务工程研究中心,江苏 南京 210023
- Keywords:
rhinitis;
medication law;
data mining;
complex network;
experience of famous doctor
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2024;31(12):49-56
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the medication law of national TCM master Gan Zuwang in the treatment of rhinitis using multivariate techniques.Methods The clinical cases of Professor Gan Zuwang's treatment of rhinitis from Jiangsu Province Hospital of Chinese Medicine from April 1984 to February 2001 were selected.Frequency statistics,co-occurrence frequency,association rules,dosage analysis and clustering analysis were used to reveal potential relationships between drugs from multiple perspectives,which were combined with the visual results of heat map,spectrogram,complex network,etc.,for intuitive presentation.Results Totally 1 080 medical cases were included,involving 1 044 prescriptions and 281 kinds of Chinese materia medica.The high-frequency drugs included Magnoliae Flos,Atractylodis Macrocephalae Rhizoma,Angelicae Dahuricae Radix,etc.;the tastes were mainly sweet,bitter and pungent,and their properties were mainly cold and warm,and most of them were classified into the lung meridian and the liver meridian.The top three drug efficacy classifications were antidepressants,purgatives and deficiency tonics.And substitute food for medicine,adding water chestnuts,jellyfish,kelp appeared in low-frequency drugs.In addition,Saposheikovize Radix-Astragali Radix-Atractylodis Macrocephalae Rhizoma,Xanthii Fructus-Menthae Haplocalycis Herba-Magnoliae Flos-Angelicae Dahuricae Radix were the core pairs,the dosage of Acori Tatarinowii Rhizoma and Angelicae Dahuricae Radix was more discrete,and the dosage of Poria was lower than the latest standardized value.Four types of formulas were finally obtained through comprehensive analyses:Yupingfeng Powder and Tuomin Decoction were used for the treatment of allergic rhinitis,Cangerzi Powder and Biyuan Mixture were used for the treatment of nasosinusitis,Shengqing Liuqi Decoction was used for the treatment of tinnitus,and Sijunzi Decoction,Senling Baizhu Powder,Yigong Powder and Buzhong Yiqi Decoction were used to strengthen spleen and tonify qi.Conclusion This study delves into the potential association between drugs and comprehensively explores Professor Gan Zuwang's medication experience in the treatment of rhinitis,which compensates for the high-frequency limitation and data bias of a single study.
