Study on the Prescription and Syndrome Law of TCM in the Treatment of Non-alcoholic Fatty Liver Disease Based on Latent Structure Model and Association Rules
10.19879/j.cnki.1005-5304.202312018
- VernacularTitle:基于隐结构模型和关联规则的中医药治疗非酒精性脂肪性肝病方证规律研究
- Author:
Xuanzi SHEN
1
;
Yuliang WANG
;
Xiaona SUN
;
Lei LUO
;
Qian CHEN
;
Yunsong SHI
;
Jingxiao ZHANG
Author Information
1. 河南中医药大学第二临床医学院,河南 郑州 450046
- Keywords:
non-alcoholic fatty liver disease;
latent structure model;
syndrome element;
association rules;
prescription and syndrome law
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2024;31(12):35-41
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore prescription and syndrome law of TCM in the treatment of non-alcoholic fatty liver disease(NAFLD);To provide reference for clinical medication.Methods The relevant literature on the treatment of NAFLD with TCM was retrieved from CNKI,VIP,Wanfang Data and CBM from the establishment of the databases to October 31,2023.Excel 2019,Lantern 5.0 and SPSS Modeler 18.0 software were used to analyze the latent structure model,association rules and frequency statistics of high-frequency drugs(≥3%)to explore the prescription and syndrome law of TCM in the treatment of NAFLD.Results A total of 453 prescriptions were included,involving 260 kinds of Chinese materia medica,with a cumulative frequency of 4 910 times.The high-frequency drugs were Crataegi Fructus,Salviea Miltiorrhizae Radix et Rhizoma,Alismatis Rhizoma,Bupleuri Radix,Poria and Atractylodis Macrocephalae Rhizoma,etc.The efficacy categories were mainly tonic medicine,diuretic dampness medicine,blood circulation-activating and stasis-resolving medicine,heat-clearing medicine and qi-regulating medicine.The latent structure model obtained 12 latent variables,24 latent classes,and 7 comprehensive clustering models.The commonly used prescriptions were Erchen Decoction,Yinchenhao Decoction,Danggui Shaoyao Powder,Sini Powder,Sijunzi Decoction,Weiling Decoction,Zhuyu Decoction and Dihuang Decoction categorized formula.Conclusion NAFLD is the syndrome of deficiency in root and excess in superficiality.Spleen deficiency is the root cause,phlegm,dampness,heat and blood stasis are the symptoms.In clinical practice,it is mainly based on tonifying qi and spleen,cooperating with the methods of resolving phlegm,eliminating dampness,clearing heat and activating blood circulation.
